The SEQTEST Procedure
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Overview
- Getting Started
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Syntax
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DetailsInput Data SetsBoundary VariablesInformation Level Adjustments at Future StagesBoundary Adjustments for Information LevelsBoundary Adjustments for Minimum Error SpendingBoundary Adjustments for Overlapping Lower and Upper beta BoundariesStochastic CurtailmentRepeated Confidence IntervalsAnalysis after a Sequential TestAvailable Sample Space Orderings in a Sequential TestApplicable Tests and Sample Size ComputationTable OutputODS Table NamesGraphics OutputODS Graphics
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ExamplesTesting the Difference between Two ProportionsTesting an Effect in a Regression ModelTesting an Effect with Early Stopping to Accept H0Testing a Binomial ProportionComparing Two Proportions with a Log Odds Ratio TestComparing Two Survival Distributions with a Log-Rank TestTesting an Effect in a Proportional Hazards Regression ModelTesting an Effect in a Logistic Regression ModelConducting a Trial with a Nonbinding Acceptance Boundary
- References
In addition to the adjusted boundary values and test results for the group sequential trial, the SEQTEST procedure also computes the following quantities:
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average sample numbers (as percentages of the corresponding fixed-sample sizes for nonsurvival data or fixed-sample numbers of events for survival data) under various hypothetical references, including the null and alternative references
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stopping probabilities at each stage under various hypothetical references to indicate how likely it is that the trial will stop at that stage
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conditional power given the most recently observed statistic under specified hypothetical references
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predictive power given the most recently observed statistic
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repeated confidence intervals for the parameter from the observed statistic at each stage
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parameter estimate, p-value for hypothesis testing, and median and confidence limits for the parameter at the conclusion of a sequential trial