The SEQDESIGN Procedure
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Overview
- Getting Started
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Syntax
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DetailsFixed-Sample Clinical TrialsOne-Sided Fixed-Sample Tests in Clinical TrialsTwo-Sided Fixed-Sample Tests in Clinical TrialsGroup Sequential MethodsStatistical Assumptions for Group Sequential DesignsBoundary ScalesBoundary VariablesType I and Type II ErrorsUnified Family MethodsHaybittle-Peto MethodWhitehead MethodsError Spending MethodsAcceptance (beta) BoundaryBoundary Adjustments for Overlapping Lower and Upper beta BoundariesSpecified and Derived ParametersApplicable Boundary KeysSample Size ComputationApplicable One-Sample Tests and Sample Size ComputationApplicable Two-Sample Tests and Sample Size ComputationApplicable Regression Parameter Tests and Sample Size ComputationAspects of Group Sequential DesignsSummary of Methods in Group Sequential DesignsTable OutputODS Table NamesGraphics OutputODS Graphics
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ExamplesCreating Fixed-Sample DesignsCreating a One-Sided O’Brien-Fleming DesignCreating Two-Sided Pocock and O’Brien-Fleming DesignsGenerating Graphics Display for Sequential DesignsCreating Designs Using Haybittle-Peto MethodsCreating Designs with Various Stopping CriteriaCreating Whitehead’s Triangular DesignsCreating a One-Sided Error Spending DesignCreating Designs with Various Number of StagesCreating Two-Sided Error Spending Designs with and without Overlapping Lower and Upper beta BoundariesCreating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject H0Creating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject or Accept H0Creating a Design with a Nonbinding Beta BoundaryComputing Sample Size for Survival Data That Have Uniform AccrualComputing Sample Size for Survival Data with Truncated Exponential Accrual
- References
Subsections:
- 89.1 Creating Fixed-Sample Designs
- 89.2 Creating a One-Sided O’Brien-Fleming Design
- 89.3 Creating Two-Sided Pocock and O’Brien-Fleming Designs
- 89.4 Generating Graphics Display for Sequential Designs
- 89.5 Creating Designs Using Haybittle-Peto Methods
- 89.6 Creating Designs with Various Stopping Criteria
- 89.7 Creating Whitehead’s Triangular Designs
- 89.8 Creating a One-Sided Error Spending Design
- 89.9 Creating Designs with Various Number of Stages
- 89.10 Creating Two-Sided Error Spending Designs with and without Overlapping Lower and Upper
Boundaries - 89.11 Creating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject
- 89.12 Creating a Two-Sided Asymmetric Error Spending Design with Early Stopping to Reject or Accept
- 89.13 Creating a Design with a Nonbinding Beta Boundary
- 89.14 Computing Sample Size for Survival Data That Have Uniform Accrual
- 89.15 Computing Sample Size for Survival Data with Truncated Exponential Accrual
The following examples demonstrate the usage of group sequential methods. Example 89.1 uses the NSTAGES=1 option to derive boundaries of critical values for a fixed-sample design. The remaining examples use different methods to create boundaries for various group sequential designs.